MOTS-c, by prescription.
Starting from
No membership fee.
Free online visit. You only pay when prescribed.
Pharmacy-made MOTS-c, prescribed to you. A US-licensed physician (MD) reviews your history online, most within 24 hours, and a licensed US pharmacy compounds your vial with your name on the label. Your online visit is free.
- Compounded in the USA by licensed 503A pharmacies and FDA-registered facilities
- Single-ingredient MOTS-c acetate
- A physician (MD) prescribes
- Subcutaneous or intramuscular injection
Compounded drug products are not approved or evaluated for safety, effectiveness, or quality by the FDA. Rx required.
Can a clinician prescribe MOTS-c now?
Yes. Since October 30, 2026, an HHS policy lets licensed 503A pharmacies compound MOTS-c acetate for a patient with a prescription, under ten conditions. The policy is enforcement discretion, which is different from FDA approval, and HHS can revise it. Your clinician decides whether MOTS-c is right for you.
Important safety information
Compounded MOTS-c is not an FDA-approved drug, and FDA has not reviewed it for safety or effectiveness. It is prepared by a licensed 503A pharmacy for one patient and dispensed only on a clinician's prescription.
What it is
A peptide written in your mitochondria
Most of your proteins are coded in the DNA of the cell's nucleus. MOTS-c is coded in the DNA of your mitochondria, the structures that make most of the cell's energy. It is a chain of 16 amino acids, one of a small family researchers call mitochondrial-derived peptides.
Until now, most MOTS-c sold online was labeled "for research use only," with no prescription, no clinician and no pharmacy label. HHS wrote its October 2026 policy to give patients "a more controlled alternative" to research-use-only peptides from foreign manufacturers.
Under that policy, a licensed 503A pharmacy can compound MOTS-c acetate for you on a clinician's prescription. Your vial holds MOTS-c and nothing else, labeled with your name, and your clinician sets the dose.
How it works
What the research looks at
Coded in your mitochondria
MOTS-c is studied as a messenger the mitochondria send to the rest of the cell. Researchers look at its role in how cells handle energy and respond to metabolic stress.
Early research, mostly animal
Most MOTS-c research is in animals and cells. Human data is limited. HHS cited a placebo-controlled trial of a MOTS-c analogue when it placed MOTS-c under its policy, and your clinician weighs that record against your history.
One ingredient, one injection
The policy covers single-ingredient MOTS-c acetate, given as a subcutaneous or intramuscular injection with an FDA-cleared syringe, on the schedule your clinician sets.
From the molecule to your vial
The molecule
Sixteen amino acids
MOTS-c is coded inside the 12S ribosomal RNA gene of human mitochondrial DNA.
The research
Studied for cellular energy
Animal and cell studies have looked at MOTS-c and how cells manage energy under stress.
The policy
October 30, 2026
HHS published a policy allowing licensed 503A pharmacies to compound MOTS-c acetate for a named patient, under ten conditions.
The pharmacy
Tested before it's compounded
The ingredient comes from an FDA-registered facility with a certificate of analysis for identity, purity, endotoxins and heavy metals.
Your clinician
Reviewed by a US-licensed clinician
A US-licensed clinician reads your history and decides whether MOTS-c fits you, and at what dose.
Educational. Compounded MOTS-c is prepared by a licensed 503A pharmacy in the USA and is not an FDA-approved drug.
What to expect
Four steps, all online.
Here is everything that happens between this page and your first vial.
Clinician-led- 1Clinician-ledWhat are you hoping MOTS-c helps with?Energy, and staying metabolically healthy as I age.
Free visit
Tell us about you
A short medical intake about your goals and history. A US-licensed clinician reviews it, most within 24 hours. The visit is free.
- 2Made for you
Your prescription
- Written by a US-licensed clinician
- Single-ingredient MOTS-c
- Licensed 503A pharmacy
Compounded in the USA
Made for you
If your clinician prescribes, a licensed 503A pharmacy fills your prescription for single-ingredient MOTS-c acetate in your name.
- 3On its way
Order status
- Prescription approved
- Compounded and inspected
- Shipped discreetly
Discreet delivery
At your door
Your vial and syringes ship within 72 hours of approval, in plain packaging.
- 4Always hereCan we talk about my dose?Of course. I'll review and adjust.
Always adjustable
Ongoing care
Message your clinician any time. Refills, dose changes and pauses run through your account.
Our standard
What HHS requires of the pharmacy
HHS's October 2026 policy sets ten conditions a licensed 503A pharmacy must meet to compound MOTS-c for a patient. Here are three of them. No hidden overseas supply chain.
Compounded in the USA
Your MOTS-c is filled by a licensed 503A pharmacy in the United States, for you by name. No hidden overseas supply chain.
A tested ingredient
The policy requires the ingredient to come from an FDA-registered facility, with a certificate of analysis for each lot covering identity, purity, endotoxins and heavy metals.
One ingredient, your name on it
Single-ingredient MOTS-c acetate, labeled for you, dispensed only on a US-licensed clinician's prescription.
Who it's for
For people who check where their peptides come from
MOTS-c through PepScribe is for adults who want it the way any other prescription works: a clinician, a pharmacy and a label with their name on it.
- You've followed the mitochondrial peptide research and want MOTS-c from a licensed pharmacy
- You've bought research-use-only vials and want to know exactly what's in yours
- You want a clinician to read your history and labs before anything is prescribed
- You want one ingredient, compounded in the USA, with nothing added
MOTS-c isn't right for everyone. If your clinician decides it isn't a fit, they'll tell you why, and you're never charged for medication you weren't prescribed.
US-licensed prescribersReal clinicians. Real prescriptions. Real follow-up.
Every MOTS-c plan is reviewed and signed by a US-licensed clinician who stays your prescriber of record. Every prescription is filled by a licensed 503A pharmacy in the United States, for you.
- A US-licensed clinician reviews every intake and remains your prescriber
- Compounded in the USA by licensed 503A pharmacies and FDA-registered facilities
- Message your clinician for adjustments throughout your plan
- The online visit is free. You only pay if you're prescribed.
What's been studied. And what hasn't.
MOTS-c was first described in 2015, and most of the research since is in animals and cells. FDA's drug center recommended against adding it to the bulks list. FDA's advisory committee voted in favor in July 2026, and HHS cited a placebo-controlled human trial of a MOTS-c analogue. Our research library lays out both sides, with sources.
- Licensed 503A pharmacies
- Compounded in the USA
- Sourced research library
503A · Compounded in the USAWhat you receive
What your MOTS-c plan includes
One monthly price covers the medication, your clinician and shipping. There is no membership fee, and you see the exact price before anything is billed.
- A free online visit with a US-licensed clinician
- A review of your intake, most within 24 hours
- Single-ingredient MOTS-c acetate, if your clinician prescribes it
- Syringes and supplies in the box
- Shipping within 72 hours of approval
- Ongoing access to your clinician for questions and adjustments
Starting from
No membership fee.
Free online visit. You only pay when prescribed.
- Cancel anytime
- No insurance needed
- Discreet shipping
- HSA/FSA eligible
Compounded MOTS-c is not an FDA-approved drug. Compounded medications are not reviewed by the FDA for safety or effectiveness. HHS's October 2026 policy is enforcement discretion, which is not FDA approval, and may be revised. Eligibility and dose are determined by a licensed clinician. No specific outcome is promised.
Compounded drug products are not approved or evaluated for safety, effectiveness, or quality by the FDA. Rx required.
MOTS-c questions
Things people ask before they sign up.
If something is not here, reach out, we'd rather answer it plainly than have you guess.
Is MOTS-c FDA-approved?
No. Compounded MOTS-c is prepared by a licensed 503A pharmacy for one patient and is not an FDA-approved drug. FDA has not reviewed it for safety or effectiveness. HHS's October 2026 policy lets pharmacies compound it under conditions. That policy is enforcement discretion, which is different from FDA approval.
What does mitochondrial-derived mean?
MOTS-c is coded in your mitochondrial DNA, a small genome separate from the one in the cell's nucleus. Researchers have identified a handful of peptides coded there, and MOTS-c is one of the most studied.
How is it taken?
As a subcutaneous or intramuscular injection, on the schedule your clinician sets. Your box includes the syringes.
What if I'm not approved?
The online visit is free, so there is nothing to refund. You are never charged for medication you were not prescribed.
How fast does it ship?
Most intakes are reviewed within 24 hours. After approval, your medication ships within 72 hours.
Can I cancel?
Yes. There are no contracts and no cancellation fees. You can pause or cancel from your account.
Start your MOTS-c visit
A few minutes of questions. A US-licensed clinician reads your answers and decides whether MOTS-c fits you. The visit is free, and you only pay if you're prescribed.