NAD+ nasal spray. Needle-free cellular energy.
A coenzyme present in every cell that supports energy production and DNA repair. Levels decline with age. Compounded NAD+ as a daily metered nasal spray, prescribed by a licensed clinician.
Starting from
Daily metered nasal spray, needle-free
Needle-free. Lower bioavailability than the injection; some patients prefer the form factor.
The online visit is free; you only pay if prescribed.
Prefer the injection? See NAD+ injection
- Compounded in the USA
- 503A-licensed
- Needle-free
Compounded drug products are not approved or evaluated for safety, effectiveness, or quality by the FDA. Rx required.
What it is
A coenzyme at the center of cellular metabolism.
NAD+ is a coenzyme central to hundreds of metabolic reactions, glycolysis, the Krebs cycle, fatty-acid oxidation. It’s also the substrate that sirtuins, PARPs, and CD38 consume to do their jobs in DNA repair, gene expression, and cellular stress response.
NAD+ levels decline with age, and that decline is associated with many of the hallmarks of aging. Compounded NAD+ aims to support the pool directly. The nasal spray is the needle-free way to dose it daily.
Your dose is prepared by a US-licensed 503A pharmacy under your clinician’s prescription. Not 503B, not international.
How it works
Mechanism of action.
Cellular energy (redox cycling)
NAD+ cycles between oxidized (NAD+) and reduced (NADH) forms in the production of ATP. Supplementation aims to maintain the cellular pool that age and exercise both deplete.
DNA repair and stress response
Sirtuins (SIRT1–7) and PARP enzymes consume NAD+ as a substrate. Higher NAD+ levels support their activity in DNA repair and cellular stress responses.
Metabolic and mitochondrial support
Linked to mitochondrial biogenesis and metabolic fitness. Research has explored roles in energy production, focus, and daily resilience.
Our standard
Compounded in the USA. Nothing less.
Safety is the whole point. Every PepScribe dose is prepared by a licensed 503A pharmacy inside the United States, prescribed by a clinician who has reviewed your history. No hidden overseas supply chain.
Compounded in the USA
Every dose is prepared inside the United States. No hidden overseas supply chain, ever.
503A-licensed pharmacy
Patient-specific compounding under your prescription, prepared to USP standards.
Clinician prescribed
A US-licensed clinician reviews your intake and writes the prescription. Never sold off a shelf.
Who it’s for
Clinician-reviewed. Not everyone qualifies.
A licensed clinician reviews your intake and recommends NAD+ only when it fits. The online visit is free; you only pay if you’re prescribed, and nothing if not.
- Considered for adults interested in cellular health, energy, and longevity goals
- Your clinician reviews your history for methylation-related considerations
- Nasal administration is needle-free; your clinician walks through metered dosing
- Labs may be ordered to personalize protocol over time
NAD+ nasal pricing
RxOne flat price for the needle-free route.
The nasal spray is a daily metered dose, no needles. Your clinician confirms it's appropriate during review.
Nasal spray
Daily metered spray
Needle-free; some patients prefer the form factor over the injection.
$159/mo
The online visit is free. You only pay if a clinician prescribes. If it isn't right for you, you pay nothing.
Compounded drug products are not approved or evaluated for safety, effectiveness, or quality by the FDA. Rx required.
What comes with the plan
Everything included.
One flat monthly price covers the medication, the clinical care, and the supplies. No surprise add-ons.
- Clinician-prescribed, US-licensed
- Compounded in the USA by a licensed 503A pharmacy
- Flat monthly pricing, medication included
- Metered nasal spray and dosing instructions
- Async clinician messaging
- HSA and FSA eligible
Compounded medications are prepared by licensed 503A pharmacies in the USA and are not FDA-approved. All prescriptions require approval by a licensed healthcare provider. Individual results may vary.
NAD+ nasal questions
Things people ask before they sign up.
If something is not here, reach out, we'd rather answer it plainly than have you guess.
What is NAD+ nasal spray?
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme present in every cell that cycles through hundreds of metabolic reactions. The nasal spray is a needle-free way to dose compounded NAD+ as a daily metered spray, prepared by a licensed 503A pharmacy under your prescription.
How is the nasal spray taken?
As a daily metered nasal spray. Your kit includes the spray and step-by-step instructions, so you can dose at home with no needles. Your clinician sets the exact protocol during review.
Nasal spray or injection, which should I choose?
The nasal spray is needle-free and convenient; the injection is the more direct route with higher bioavailability. Many patients pick the nasal spray for the form factor. If you would prefer the injectable, see the NAD+ injection page. Your clinician confirms what is appropriate during review.
When might I notice a difference?
NAD+ works gradually. Most people are evaluating energy and daily resilience over the first several weeks to a few months of consistent use, not days.
Is it FDA-approved?
Compounded NAD+ is not an FDA-approved drug. It is prepared by a licensed 503A pharmacy in the USA under your clinician’s prescription for patients with a documented clinical need.
How much does the NAD+ nasal spray cost through PepScribe?
The online visit is free; you only pay if you are prescribed, and nothing if not. After approval, the nasal spray is a flat $159/month, or $447 per quarter on the 3-month plan (about $149/mo). One flat price covers the medication, the clinical care, and the supplies, with no surprise add-ons. Plans are HSA and FSA eligible.
Who prescribes it, and do I need an in-person visit?
A US-licensed clinician is the prescriber of record. They review your intake history and write the prescription only when NAD+ is appropriate. No in-person visit is required: the assessment is completed online and reviewed asynchronously, typically within 24 hours. After you start, you also get async clinician messaging.
Start NAD+ nasal spray.
Three-minute assessment. A US-licensed clinician reviews it within 24 hours. The online visit is free; you only pay if NAD+ is prescribed.