NAD+. Every cell in your body runs on this.
A coenzyme present in every cell that supports energy production and DNA repair. Levels decline with age. Compounded NAD+ as a subcutaneous injection, the most direct route, prescribed by a licensed clinician.
Starting from
Daily or every-other-day subcutaneous injection
The direct route, highest bioavailability.
The online visit is free; you only pay if prescribed.
Prefer needle-free? See NAD+ nasal spray
- Compounded in the USA
- 503A-licensed
- Clinician-prescribed
Compounded drug products are not approved or evaluated for safety, effectiveness, or quality by the FDA. Rx required.
PepScribe is a LegitScript-certified telehealth practice. See how to verify us.
What it is
A coenzyme at the center of cellular metabolism.
NAD+ is a coenzyme central to hundreds of metabolic reactions, glycolysis, the Krebs cycle, fatty-acid oxidation. It’s also the substrate that sirtuins, PARPs, and CD38 consume to do their jobs in DNA repair, gene expression, and cellular stress response.
NAD+ levels decline with age, and that decline is associated with many of the hallmarks of aging. Compounded NAD+ aims to support the pool directly rather than relying on the less-efficient uptake of oral precursors.
Your dose is prepared by a US-licensed 503A pharmacy under your clinician’s prescription. Not 503B, not international.
How it works
Mechanism of action.
Cellular energy (redox cycling)
NAD+ cycles between oxidized (NAD+) and reduced (NADH) forms in the production of ATP. Supplementation aims to maintain the cellular pool that ages and exercise both deplete.
DNA repair and stress response
Sirtuins (SIRT1–7) and PARP enzymes consume NAD+ as a substrate. Higher NAD+ levels support their activity in DNA repair and cellular stress responses.
Metabolic and mitochondrial support
Linked to mitochondrial biogenesis and metabolic fitness. Research has explored roles in energy production, focus, and daily resilience.
Our standard
Compounded in the USA. Nothing less.
Safety is the whole point. Every PepScribe dose is prepared by a licensed 503A pharmacy inside the United States, prescribed by a clinician who has reviewed your history. No hidden overseas supply chain.
Compounded in the USA
Every dose is prepared inside the United States. No hidden overseas supply chain, ever.
503A-licensed pharmacy
Patient-specific compounding under your prescription, prepared to USP standards.
Clinician prescribed
A US-licensed clinician reviews your intake and writes the prescription. Never sold off a shelf.
Who it’s for
Clinician-reviewed. Not everyone qualifies.
A licensed clinician reviews your intake and recommends NAD+ only when it fits. The online visit is free; you only pay if you're prescribed, and nothing if not.
- Considered for adults interested in cellular health, energy, and longevity goals
- Your clinician reviews your history for methylation-related considerations
- Injection-site reactions are possible with the injectable form; your clinician walks through dosing and technique
- Labs may be ordered to personalize protocol over time
NAD+ injection pricing
RxOne flat price for the direct route.
The injection is the most direct route, with the highest bioavailability. A US-licensed clinician confirms it's appropriate during review.
Injectable
Daily or every-other-day subcutaneous
The direct route, highest bioavailability.
$228/mo
The online visit is free. You only pay if a clinician prescribes. If it isn't right for you, you pay nothing.
Compounded drug products are not approved or evaluated for safety, effectiveness, or quality by the FDA. Rx required.
What comes with the plan
Everything included.
One flat monthly price covers the medication, the clinical care, and the supplies. No surprise add-ons.
- Clinician-prescribed, US-licensed
- Compounded in the USA by a licensed 503A pharmacy
- Flat monthly pricing, medication included
- Supplies and dosing instructions
- Async clinician messaging
- HSA and FSA eligible
Compounded medications are prepared by licensed 503A pharmacies in the USA and are not FDA-approved. All prescriptions require approval by a licensed healthcare provider. Individual results may vary.
NAD+ questions
Things people ask before they sign up.
If something is not here, reach out, we'd rather answer it plainly than have you guess.
What is NAD+?
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme present in every cell. It cycles through hundreds of metabolic reactions and is the substrate sirtuins and PARP enzymes use for DNA repair and cellular stress response. Levels decline with age, and supplementation is designed to support the cellular pool that fuels energy production.
How is it taken?
Two ways, depending on what your clinician prescribes: a small subcutaneous injection on a daily or every-other-day schedule, or a daily metered nasal spray. Your kit includes the supplies and step-by-step instructions, so you can dose at home.
When might I notice a difference?
NAD+ works gradually. Most people are evaluating energy and daily resilience over the first several weeks to a few months of consistent use, not days.
Is it FDA-approved?
Compounded NAD+ is not an FDA-approved drug. It is prepared by a licensed 503A pharmacy in the USA under your clinician’s prescription for patients with a documented clinical need.
What if I am not approved?
The online visit is free; you only pay if you are prescribed, and nothing if not.
How do I get NAD+ prescribed online?
Start with the free three-minute assessment. A US-licensed clinician reviews your intake, typically within 24 hours, and writes the prescription only when NAD+ fits your history and goals. If approved, your dose is compounded in the USA by a licensed 503A pharmacy under that prescription and shipped to you with supplies and step-by-step dosing instructions, so you can dose at home. No hidden overseas supply chain.
How much does NAD+ therapy cost through PepScribe?
The online visit is free; you only pay if you are prescribed, and nothing if not. After approval, pricing is a flat monthly amount set by the form you choose: the injectable is $228/month and the nasal spray is $159/month. One flat monthly price covers the medication, the clinical care, and the supplies, with no surprise add-ons. Plans are HSA and FSA eligible.
Who prescribes NAD+, and do I need an in-person visit?
A US-licensed clinician is the prescriber of record. They review your intake history and write the prescription only when NAD+ is appropriate. No in-person visit is required: the assessment is completed online and the clinician reviews it asynchronously, typically within 24 hours. After you start, you also get async clinician messaging. NAD+ is clinician-prescribed and never sold off a shelf.
Is NAD+ therapy available in my state?
NAD+ is prescribed by US-licensed clinicians, and whether it is available to you is confirmed when a clinician reviews your assessment. The quickest way to check is to take the free three-minute assessment; the clinician review confirms eligibility, including where you can be treated, before any prescription is issued. The online visit is free; you only pay if you are prescribed, and nothing if not.
Start an NAD+ plan.
Three-minute assessment. A US-licensed clinician reviews it within 24 hours. The online visit is free; you only pay if NAD+ is prescribed.