Tirzepatide. Two pathways. One injection.
A dual GLP-1 / GIP receptor agonist that engages two incretin pathways in one molecule. Weekly subcutaneous injection, compounded in the USA under 503A rules.
Starting from
No membership fee.
- Compounded in the USA
- Filled by 503A
- Clinician-prescribed
Compounded drug products are not approved or evaluated for safety, effectiveness, or quality by the FDA. Rx required.
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What it is
A dual-incretin peptide, compounded under 503A.
Tirzepatide is a synthetic peptide that activates two incretin receptors, GLP-1 and GIP, in a single molecule. Both hormones are released by the gut in response to food; together they regulate insulin, glucagon, appetite, and gastric motility.
Branded tirzepatide products are FDA-approved finished drugs. Compounded tirzepatide is a different thing: prepared by a US-licensed 503A pharmacy under a clinician’s prescription, for patients with documented clinical need. It is not FDA-approved.
Your dose is prepared by a US-licensed 503A pharmacy under your clinician’s prescription. No hidden overseas supply chain.
Prefer a daily tablet? Compounded oral tirzepatide is also available by prescription after the same clinician review. It is not FDA-approved either.
How it works
Mechanism of action.
Dual incretin action
Activates both GLP-1 and GIP receptors simultaneously. These incretins work through complementary pathways, together they produce stronger effects on appetite and glucose regulation than either alone.
Appetite + glucose regulation
Combined GLP-1/GIP engagement may produce greater effects on appetite regulation and glycemic control than GLP-1 agonism alone, based on published clinical data.
Once-weekly pharmacokinetics
Long half-life supporting once-weekly subcutaneous dosing. Steady-state levels reached over the first several weeks on a titrated protocol.
How long it stays in your blood
Your own GLP‑1 is gone in minutes. Tirzepatide lasts for days.
The gut hormones GLP-1 and GIP are broken down by an enzyme within minutes of release. Tirzepatide acts on both receptors and carries a fatty side chain that binds albumin, a protein in your blood, so about half of a dose is still circulating five days later.
Show as a table
| Time in the blood | Natural GLP-1 | Natural GIP | Tirzepatide |
|---|---|---|---|
| 1 min | 74% | 87% | 100% |
| 2.3 min | 50% | 73% | 100% |
| 10 min | 4.9% | 25% | 100% |
| 1 hour | 0% | 0% | 99% |
| 1 day | 0% | 0% | 87% |
| 4.9 days | 0% | 0% | 50% |
| 7 days | 0% | 0% | 37% |
| 28 days | 0% | 0% | 1.8% |
Why it is once a week
Each dose lands before the last one is gone.
Tirzepatide clears slowly, so each weekly dose arrives while part of the previous one is still in circulation. Over about four weeks the doses stack into a steady pattern that rises and settles the same way every week.
Our standard
Compounded in the USA. Filled by licensed 503A pharmacies.
Every PepScribe dose is prepared by a licensed 503A pharmacy inside the United States, prescribed by a clinician who has reviewed your history. No hidden overseas supply chain.
Compounded in the USA
Every dose is prepared inside the United States. No hidden overseas supply chain, ever.
Filled by a 503A pharmacy
Compounded in the USA to USP standards and filled under your prescription by a licensed 503A pharmacy.
Clinician prescribed
A US-licensed clinician reviews your intake and writes the prescription. Never sold off a shelf.
Who it’s for
For adults with weight-management goals. Reviewed by a licensed clinician.
A licensed clinician reviews your intake, typically within 24 hours, and screens for the conditions below. The online visit is free; you only pay if you're prescribed, and nothing if not.
- Considered for adults with clinical eligibility for dual-incretin therapy
- Your clinician reviews your history for thyroid conditions (MTC/MEN2), pancreatitis, and pregnancy
- Not prescribed during pregnancy, active thyroid malignancy, or certain GI conditions
- Labs and vitals may be ordered; results inform dose titration
Switching providers
Already on tirzepatide? Continue at your dose.
If you take tirzepatide now, your intake asks which medication you take, the dose you’re on, and when your last dose was, so your clinician sees exactly where you are.
Report where you are
The online visit is free. You tell us your current medication, the dose you're on, and how long you've been on it. Nothing is charged at booking.
Your clinician decides
A US-licensed clinician reviews your history, decides whether to prescribe, and sets your dose at your visit.
Billed by the prescribed band
If prescribed, you're charged the dose band on the schedule below that matches the prescription, not the dose you reported. Your price only rises if your dose does.
Dose-banded pricing
RxPick the plan your clinician prescribes.
Compounded tirzepatide is dosed in titration steps. Your clinician selects the band based on your intake, history, and response. Lower doses are where most patients start.
Starter
2.5 – 5 mg
from $149/mo
Standard
7.5 – 10 mg
from $209/mo
Maintenance
12.5 – 15 mg
from $279/mo
The online visit is free. You only pay if a clinician prescribes. If it isn't right for you, you pay nothing.
Compounded drug products are not approved or evaluated for safety, effectiveness, or quality by the FDA. Rx required.
How the dose steps up
New plans start low and step up every four weeks.
New tirzepatide patients usually start at the lowest dose and move up every four weeks, the escalation schedule used in the pivotal trial. Your clinician decides each step and can hold or lower a dose.
Show as a table
| Weeks | Weekly dose |
|---|---|
| 1 to 4 | 2.5 mg |
| 5 to 8 | 5 mg |
| 9 to 12 | 7.5 mg |
| 13 to 16 | 10 mg |
| 17 to 20 | 12.5 mg |
| 21 on | 15 mg |
What comes with the plan
Everything included.
One flat monthly price covers the medication, the clinical care, and the supplies. No surprise add-ons.
- Clinician-prescribed, US-licensed
- Compounded in the USA by a licensed 503A pharmacy
- Flat monthly pricing, medication included
- Supplies and injection instructions
- Async clinician messaging
- HSA and FSA eligible
Compounded tirzepatide is prepared by licensed 503A pharmacies and FDA-registered facilities in the USA and is not FDA-approved. The branded injectable tirzepatide products are separate FDA-approved drugs produced by their manufacturers. All prescriptions require approval by a licensed healthcare provider. Individual results may vary.
Tirzepatide questions
Things people ask before they sign up.
If something is not here, reach out, we'd rather answer it plainly than have you guess.
How is compounded tirzepatide different from the branded injectable?
They are separate things. The branded tirzepatide injectables are FDA-approved finished drugs made by their manufacturers. Compounded tirzepatide is prepared by a US-licensed 503A pharmacy under your clinician’s prescription, for patients with a documented clinical need. It is prescribed as a specialty line when a compounded formulation is clinically appropriate.
How is it taken?
A small subcutaneous injection, taken once weekly on a titrated protocol your clinician sets. Your kit includes the supplies and step-by-step instructions, and most people start at a lower dose and step up over time.
Is tirzepatide available as a tablet?
Yes. Compounded oral tirzepatide is a once-daily tablet, prescribed after the same clinician review and compounded in the USA by a licensed 503A pharmacy. Like the injection, it is not FDA-approved. Your clinician can talk through which form fits you.
When might I notice a difference?
Tirzepatide works gradually on a titration schedule. Steady-state levels are reached over the first several weeks, and most people are evaluating appetite and progress over months of consistent weekly use.
Is it FDA-approved?
Compounded tirzepatide is not an FDA-approved drug. It is prepared by a licensed 503A pharmacy in the USA under your clinician’s prescription for patients with a documented clinical need.
What if I am not approved?
The online visit is free; you only pay if you are prescribed, and nothing if not.
How do I get compounded tirzepatide prescribed online?
Start with the free three-minute assessment online. A US-licensed clinician reviews your intake, usually within 24 hours. If they prescribe compounded tirzepatide, your dose is compounded in the USA by a licensed 503A pharmacy under that prescription, then shipped to you with the supplies and step-by-step injection instructions. The whole flow is online, including async clinician messaging, and the online visit is free; you only pay if you are prescribed.
How much does compounded tirzepatide cost online?
Plans start from $149/mo, with the medication included. Pricing is dose-banded, so what you pay depends on the dose your clinician prescribes: Starter (2.5 to 5 mg) from $149/mo, Standard (7.5 to 10 mg) from $209/mo, and Maintenance (12.5 to 15 mg) from $279/mo. Your clinician selects the band based on your intake and response, most patients start at a lower dose, and you see the exact plan price before you pay anything. The online visit is free; you only pay if you are prescribed, and nothing if not. Plans are HSA and FSA eligible.
Who prescribes the compounded tirzepatide, and do I need an in-person visit?
A US-licensed clinician is the prescriber of record. They review your intake online and write the prescription only when compounded tirzepatide is appropriate for you. The assessment and review happen online with async clinician messaging, and the clinician typically reviews your intake within 24 hours. It is never sold off a shelf.
Is compounded tirzepatide available in my state?
Because a US-licensed clinician must be the prescriber of record and prescribe under your specific intake and history, availability depends on having a clinician licensed where you live. The fastest way to confirm coverage for your location is the free three-minute assessment. The online visit is free; you only pay if you are prescribed, and nothing if not, so there is no risk in checking.
Start a Tirzepatide plan.
Three-minute assessment. A US-licensed clinician reviews it within 24 hours. The online visit is free; you only pay if tirzepatide is prescribed.