PepScribe
A PepScribe-branded compounded bioidentical estradiol capsule bottle, angled against a soft studio backdrop.
A bioidentical hormone

Estradiol, the estrogen at the center of menopause care.

Starting from

$89/mo

No membership fee.

Take the free assessment

Free online visit. You only pay when prescribed.

Estradiol is the main estrogen your body makes less of through the menopausal transition. A US-licensed clinician reviews your symptoms and, where indicated, your labs, then sets the form and dose. Compounded in the USA by licensed 503A pharmacies. No hidden overseas supply chain.

  • Clinician-led, US-licensed
  • Bioidentical estradiol
  • Labs reviewed where indicated
  • Compounded in the USA by licensed 503A pharmacies

Compounded drug products are not approved or evaluated for safety, effectiveness, or quality by the FDA. Rx required.

A warm American woman in her mid fifties leaning against a sunlit wall, relaxed and confident with real age texture.

What it is

The estrogen your body makes less of in menopause

Estradiol is the primary form of estrogen in the body, and its decline drives many of the recognized changes of perimenopause and menopause. Bioidentical estradiol is structurally identical to the estradiol your body produces, and your clinician can prescribe it as an oral form for whole-body symptoms or a vaginal form focused on local symptoms, depending on your picture.

A US-licensed clinician reviews your history and, where it informs the decision, your labs, and writes your prescription. If you have a uterus, estradiol is typically prescribed alongside progesterone to protect the uterine lining. Every dose is compounded in the USA by a licensed 503A pharmacy. Compounded estradiol is not an FDA-approved drug.

How it fits your plan

Form, pairing, and monitoring

01

Oral or vaginal

Your clinician selects the form from your symptoms. An oral form addresses whole-body symptoms such as hot flashes and night sweats; a vaginal form focuses on local symptoms such as dryness. The choice is a clinical one, made with you.

02

Paired with progesterone when needed

For women with a uterus, estrogen is prescribed together with progesterone to protect the uterine lining. Your clinician manages this pairing so your plan is complete.

03

Reviewed and adjusted

Where it informs the decision, your clinician reviews estradiol and related labs, and adjusts the form or dose over time as your symptoms and history evolve. HRT is ongoing care.

Sourcing and safety

Bioidentical, US-compounded, and prescribed by a clinician of record.

You know who writes the prescription and which licensed 503A pharmacy compounds your estradiol.

A clinician of record

A US-licensed clinician reviews your intake, discusses the trade-offs and the medical evidence, and is your prescriber of record.

Compounded in the USA

Your bioidentical estradiol is compounded in the USA by a licensed 503A pharmacy under your prescription. No hidden overseas supply chain.

Labs where indicated

Where it informs the decision, your clinician reviews estradiol and related hormone panels so your plan reflects what your body is missing.

An American woman in her early fifties standing on an open path outdoors, serene and self-assured.

Who it's for

For women navigating the estrogen decline of menopause, who want a clinician who listens.

Estradiol is considered for women with symptoms of the menopausal transition, reviewed against their history and, where indicated, their labs. Eligibility is a clinical decision made by your prescriber.

  • Hot flashes, night sweats, or disrupted sleep that track with the menopausal transition
  • Vaginal dryness or local symptoms that affect comfort and intimacy
  • Mood, focus, or energy changes you want evaluated as part of the hormonal picture
  • You want bioidentical estrogen prescribed and monitored by a clinician

Your clinician reviews your history for contraindications including a personal history of hormone-sensitive cancers, blood clots, or cardiovascular disease, and prescribes only when the evidence supports it. Not everyone qualifies, and if estradiol is not appropriate you are never charged for a medication you were not prescribed.

A PepScribe-branded compounded bioidentical estradiol capsule bottle on a sunlit bathroom counter beside a rolled towel and a glass of water.

What you receive

One plan. Everything included.

A flat monthly price covers your compounded medication, the clinical care, and shipping. Your clinician sets the exact form and dose during your review and adjusts it over time.

  • Bioidentical estradiol prescribed for you, oral or vaginal, US-licensed
  • Compounded in the USA by a licensed 503A pharmacy
  • Progesterone pairing where clinically indicated
  • Lab review where indicated, including hormone panels
  • Async messaging with your care team and dose adjustments over time
  • Cancel or pause anytime

Starting from

$89/mo

No membership fee.

Take the free assessment

Free online visit. You only pay when prescribed.

  • Cancel anytime
  • No insurance needed
  • Discreet shipping
  • HSA/FSA eligible

Compounded estradiol is not an FDA-approved drug. Bioidentical hormone therapy is not appropriate for everyone. Form, dose, and any companion hormones are determined by a licensed clinician based on your history and, where indicated, your labs.

Compounded drug products are not approved or evaluated for safety, effectiveness, or quality by the FDA. Rx required.

Estradiol questions

Things people ask before they sign up.

If something is not here, reach out, we'd rather answer it plainly than have you guess.

What is bioidentical estradiol?

Estradiol is the main estrogen your body produces. Bioidentical estradiol is structurally identical to it, compounded in the USA by a licensed 503A pharmacy under your prescription. It is prescribed by a US-licensed clinician and is not an FDA-approved drug.

Is it taken orally or vaginally?

Both forms exist, and your clinician selects the one that fits your symptoms. An oral form addresses whole-body symptoms such as hot flashes; a vaginal form focuses on local symptoms such as dryness. Your clinician decides with you.

Do I need progesterone too?

If you have a uterus, estrogen is typically prescribed alongside progesterone to protect the uterine lining. Your clinician manages this pairing as part of a complete plan.

Will my labs be reviewed first?

Where it informs the decision, yes. Your clinician may review estradiol and related hormone panels so your plan reflects what your body needs.

How much does it cost?

The online visit is free. If a clinician prescribes, hormone therapy plans start from $89/mo, and you see the exact plan price before you pay anything. One price includes the medication, clinician care, and shipping. Plans are HSA and FSA eligible.

Estradiol, prescribed online.

Take the free assessment. A US-licensed clinician reviews your symptoms and, where indicated, your labs, and sets your estradiol form and dose. The online visit is free, and you only pay if you're prescribed.