Low-dose naltrexone, considered, not prescribed by default.
LDN is naltrexone taken at a fraction of its standard dose. It is used off-label and reviewed by a US-licensed clinician as part of a whole-body wellness approach, weighed against your history and goals before anything is prescribed.
- Compounded in the USA by licensed 503A pharmacies
- Prescribed off-label by US-licensed clinicians
- No hidden overseas supply chain
- The online visit is free, you only pay if you're prescribed
Compounded drug products are not approved or evaluated for safety, effectiveness, or quality by the FDA. Rx required.
What it is
Naltrexone, at a low dose, used off-label
Naltrexone is a long-established medication. At its standard dose it is FDA-approved for other uses. Low-dose naltrexone, or LDN, refers to the same molecule compounded at a much smaller dose, typically a small fraction of the standard amount.
Used this way, LDN is an off-label therapy. That means a clinician is prescribing a recognized medication outside its approved labeling, based on their clinical judgment and your individual history. Low-dose compounded LDN is not itself an FDA-approved drug.
At PepScribe, LDN is considered as one part of a broader wellness conversation. It is prescribed only when a clinician decides it is appropriate for you, never sold off a shelf and never the default answer.
The idea behind it
Why the dose is the whole point
A small, daily dose
LDN is compounded at a low dose and usually taken once daily, often at night. The low amount is deliberate. It is what distinguishes this off-label use from naltrexone's standard-dose, FDA-approved uses.
Still being studied
Low-dose naltrexone is the subject of ongoing research, and the science is still developing. That uncertainty is exactly why a clinician weighs it case by case rather than prescribing it broadly, and makes no promises about what it will do for you.
Personalized over time
If LDN is prescribed, your clinician may adjust the dose and check in through async messaging. The goal is a protocol matched to you and your goals, refined over weeks, not a one-size dose handed out at sign-up.
How we source it
Compounded in the USA, with nothing to hide.
Where your medication is made matters. Every LDN prescription is compounded inside the United States by a licensed 503A pharmacy, under your clinician's order.
Compounded in the USA
Every dose is prepared inside the United States. No hidden overseas supply chain, ever.
503A-licensed pharmacy
Patient-specific compounding under your prescription, prepared to USP standards by a US-licensed 503A pharmacy.
Clinician prescribed
A US-licensed clinician reviews your intake and writes the prescription off-label only when LDN fits. Never sold off a shelf.
Who it is for
A considered fit, not a catch-all.
LDN is reviewed as part of a broader wellness picture. These are the kinds of signals a clinician weighs during your assessment. They are starting points for a conversation, not a checklist that qualifies you.
- Adults interested in a clinician-guided approach to whole-body wellness
- An interest in a clinician-led conversation about everyday wellness, energy, and sleep quality
- A preference for an established medication used thoughtfully and off-label
- Comfort with a therapy that is taken daily and refined over time
- Openness to a clinician deciding LDN is not the right fit, and saying so
Your clinician reviews your full history, current medications, and goals. LDN is prescribed only when it is appropriate for you, and the same review may conclude it is not.
What you receive
One flat monthly plan, set during your visit
Your online visit is free. You only pay if a clinician prescribes, and one monthly price then covers the medication, the clinical care, and the supplies, with no surprise add-ons.
- Clinician-prescribed off-label, by a US-licensed clinician
- Compounded in the USA by a licensed 503A pharmacy
- Flat monthly pricing, medication included
- Dosing instructions tailored to your protocol
- Async clinician messaging for questions and adjustments
- HSA and FSA eligible
Starting from
Free online visit. You only pay when prescribed.
- Cancel anytime
- No insurance needed
- Discreet shipping
- HSA/FSA eligible
Low-dose compounded naltrexone is not an FDA-approved drug. It is prescribed off-label, at a clinician's discretion, and compounded in the USA by a licensed 503A pharmacy under your prescription. The online visit is free. Standard-dose naltrexone is FDA-approved for other uses.
Compounded drug products are not approved or evaluated for safety, effectiveness, or quality by the FDA. Rx required.
LDN questions
Things people ask before they sign up.
If something is not here, reach out, we'd rather answer it plainly than have you guess.
What is low-dose naltrexone (LDN)?
LDN is naltrexone compounded at a low dose, a small fraction of the standard amount, and taken once daily. Standard-dose naltrexone is a long-established, FDA-approved medication for other uses. At a low dose it is used off-label, meaning a clinician prescribes a recognized medication outside its approved labeling based on their judgment and your history. At PepScribe it is considered as one part of a whole-body wellness approach.
Is LDN FDA-approved?
Low-dose compounded naltrexone is not an FDA-approved drug. Standard-dose naltrexone is FDA-approved for other uses, but the low-dose compounded form used here is prescribed off-label, at a clinician's discretion, and prepared by a licensed 503A pharmacy in the USA under your prescription. We never imply FDA approval for the compounded low-dose form.
What does off-label mean here?
Off-label means a clinician is prescribing a recognized, established medication outside its approved labeling, based on their clinical judgment and your individual situation. It is a common and legal part of medical practice. With LDN, the clinician decides whether this off-label use is appropriate for you, and may decide it is not.
How is LDN taken?
If prescribed, LDN is typically taken once daily, often at night, at the low dose your clinician sets. Your plan includes dosing instructions, and your clinician may adjust the dose over time through async messaging. The exact form and schedule are personalized to you.
How do I get LDN prescribed online?
Start with the free three-minute assessment. A US-licensed clinician reviews your intake, typically within 48 hours, and prescribes LDN off-label only when it fits your history and goals. If approved, your dose is compounded in the USA by a licensed 503A pharmacy under that prescription and shipped to you with dosing instructions. No hidden overseas supply chain.
How much does LDN cost through PepScribe?
The online visit is free. If a clinician prescribes, LDN is from $69/month on the 3-month plan (or $89/month billed monthly). One price includes the medication, clinician care, and shipping. Plans are HSA and FSA eligible.
What if I am not approved?
The online visit is free, so there is nothing to refund. You are never charged for a medication you were not prescribed. A clinician may decide it is not the right fit for you, and that is part of responsible care.
Who prescribes LDN, and do I need an in-person visit?
A US-licensed clinician is the prescriber of record. They review your intake history and prescribe LDN off-label only when it is appropriate. No in-person visit is required: the assessment is completed online and the clinician reviews it asynchronously, typically within 48 hours. After you start, you also get async clinician messaging. LDN is clinician-prescribed and never sold off a shelf.
Is LDN available in my state?
LDN is prescribed by US-licensed clinicians, and whether it is available to you is confirmed when a clinician reviews your assessment. The quickest way to check is to take the free three-minute assessment; the clinician review confirms eligibility, including where you can be treated, before any prescription is issued. The online visit is free, and you only pay if you're prescribed.
See whether LDN fits, the careful way
Take the free three-minute assessment. A US-licensed clinician reviews your history and decides whether low-dose naltrexone is appropriate for you. The online visit is free, and you only pay if you're prescribed.