Sermorelin. Support what your body already does.
A growth-hormone-releasing hormone analog that signals your pituitary to release GH naturally. One small injection a night, before bed.
Starting from
- Compounded in the USA
- 503A-licensed
- Clinician-prescribed
Compounded drug products are not approved or evaluated for safety, effectiveness, or quality by the FDA. Rx required.
PepScribe is a LegitScript-certified telehealth practice. See how to verify us.
What it is
A GHRH analog, not synthetic HGH.
Sermorelin is a short peptide that mirrors an active fragment of natural GHRH, the hypothalamic hormone that tells your pituitary to release growth hormone. It was first developed in the 1980s for growth-hormone evaluation.
The difference from synthetic HGH is the mechanism. Synthetic GH bypasses the pituitary and floods the system. Sermorelin nudges the pituitary to do its own job, so your natural feedback loops stay intact.
Your dose is prepared by a US-licensed 503A pharmacy under your clinician’s prescription. Not 503B, not international.
How it works
Mechanism of action.
Pulsatile GH release
Binds GHRH receptors in the anterior pituitary, prompting natural pulsatile growth-hormone release rather than a constant flood.
Preserves feedback loops
Works with the hypothalamic-pituitary axis' native negative feedback, the pituitary backs off when somatostatin signals rise.
Recovery, sleep, body composition
Elevated endogenous GH and IGF-1 support tissue repair, deeper sleep architecture, and body composition over months of consistent use.
Our standard
Compounded in the USA. Nothing less.
Safety is the whole point. Every PepScribe dose is prepared by a licensed 503A pharmacy inside the United States, prescribed by a clinician who has reviewed your history. No hidden overseas supply chain.
Compounded in the USA
Every dose is prepared inside the United States. No hidden overseas supply chain, ever.
503A-licensed pharmacy
Patient-specific compounding under your prescription, prepared to USP standards.
Clinician prescribed
A US-licensed clinician reviews your intake and writes the prescription. Never sold off a shelf.
Who it’s for
Clinician-reviewed. Not everyone qualifies.
A licensed clinician reviews your intake and recommends sermorelin only when it fits. The online visit is free; you only pay if you're prescribed, and nothing if not.
- Considered for adults with goals around recovery, sleep quality, and body composition
- Your clinician reviews your history for pituitary, thyroid, and endocrine contraindications
- Not prescribed during pregnancy, active cancer, or known pituitary disease
- Labs may be ordered before prescribing, results inform dosing
Sermorelin pricing
RxOne plan. Everything included.
Sermorelin is dosed in a single nightly subcutaneous step. Your clinician sets the exact unit dose during your consult based on your intake.
Single dose
Nightly subcutaneous
Includes clinician care, syringes, and shipping.
$169/mo
The online visit is free. You only pay if a clinician prescribes. If it isn't right for you, you pay nothing.
Compounded drug products are not approved or evaluated for safety, effectiveness, or quality by the FDA. Rx required.
What comes with the plan
Everything included.
One flat monthly price covers the medication, the clinical care, and the supplies. No surprise add-ons.
- Clinician-prescribed, US-licensed
- Compounded in the USA by a licensed 503A pharmacy
- Flat monthly pricing, medication included
- Supplies and injection instructions
- Async clinician messaging
- Cancel or pause anytime
Compounded medications are prepared by licensed 503A pharmacies in the USA and are not FDA-approved. All prescriptions require approval by a licensed healthcare provider. Individual results may vary.
Sermorelin questions
Things people ask before they sign up.
If something is not here, reach out, we'd rather answer it plainly than have you guess.
Is sermorelin the same as HGH?
No. Synthetic HGH floods the body with growth hormone directly. Sermorelin is a GHRH analog that signals your own pituitary to release growth hormone naturally, which keeps your body’s feedback loops intact.
How is it taken?
A small subcutaneous injection, taken nightly before bed to mirror your natural overnight GH pulse. Your kit includes the supplies and step-by-step instructions.
When might I notice a difference?
Sermorelin works gradually. Most people are evaluating sleep quality and recovery over the first one to three months of consistent nightly use, not days.
Is it FDA-approved?
Compounded sermorelin is not an FDA-approved drug. It is prepared by a licensed 503A pharmacy in the USA under your clinician’s prescription for patients with a documented clinical need.
What if I am not approved?
The online visit is free; you only pay if you are prescribed, and nothing if not.
Can I pause or cancel?
Yes, anytime, with no penalty. Message your care team and we handle it.
How do I get sermorelin prescribed online through PepScribe?
It is a fully online process. You start with a free three-minute assessment, and a US-licensed clinician reviews your intake within 24 hours. If sermorelin fits your history and goals, the clinician writes the prescription and your dose is compounded in the USA by a licensed 503A pharmacy under that prescription. Your kit ships to you with the supplies and step-by-step injection instructions, and sermorelin is taken as one small subcutaneous injection nightly before bed.
How much does sermorelin therapy cost at PepScribe?
Sermorelin is $169 per month, or $459 per quarter on the 3-month plan (about $153/mo). The online visit is free; you only pay if you are prescribed, and nothing if not. The flat monthly price covers the medication, the clinical care, the supplies, and shipping, with no surprise add-ons. Sermorelin uses a single nightly subcutaneous dose, and your clinician sets the exact unit dose during your consult based on your intake.
Who prescribes sermorelin, and do I need an in-person visit?
A US-licensed clinician reviews your intake and is the prescriber of record. Sermorelin is never sold off a shelf. The review is asynchronous, so you complete the online assessment and the clinician evaluates it and messages you through async clinician messaging. The page describes an online intake and clinician review within 24 hours rather than an in-person visit.
Which states is sermorelin available in?
Sermorelin is prescribed by US-licensed clinicians, so availability depends on where a clinician is licensed to prescribe and on your individual eligibility. Not everyone qualifies, and the clinician recommends sermorelin only when it fits your history and goals. The free three-minute assessment confirms whether a clinician can prescribe for you before you pay anything, since the online visit is free; you only pay if you are prescribed.
Start a Sermorelin plan.
Three-minute assessment. A US-licensed clinician reviews it within 24 hours. The online visit is free; you only pay if sermorelin is prescribed.