PepScribe
A PepScribe-branded compounded bioidentical progesterone capsule bottle, angled against a soft studio backdrop.
A bioidentical hormone

Progesterone, for balance, sleep, and uterine protection.

Starting from

$139/mo
Take the free assessment

Free online visit. You only pay when prescribed.

Progesterone is the calming counterpart to estrogen, and its decline in perimenopause can affect sleep and mood. A US-licensed clinician reviews your symptoms and, where indicated, your labs, then prescribes bioidentical progesterone only when it fits your history. Compounded in the USA by licensed 503A pharmacies. No hidden overseas supply chain.

  • Clinician-led, US-licensed
  • Bioidentical progesterone
  • Labs reviewed where indicated
  • Compounded in the USA by licensed 503A pharmacies

Compounded drug products are not approved or evaluated for safety, effectiveness, or quality by the FDA. Rx required.

An American woman in her early fifties waking gently at the edge of her bed in soft morning light, calm and rested.

What it is

The calming hormone, prescribed as real medical care

Progesterone is the hormone that balances estrogen through the menstrual cycle, and it declines early in the menopausal transition. Bioidentical progesterone is structurally identical to what your body makes, and your clinician can prescribe it as an oral capsule, often taken at night for its calming effect, or as a topical, depending on your picture.

Progesterone plays two roles. For women with a uterus taking estrogen, it protects the uterine lining, so it is prescribed as part of a complete plan. On its own, it is used to support sleep and mood during perimenopause. A US-licensed clinician reviews your history and, where indicated, your labs, and writes a prescription only when appropriate. Every dose is compounded in the USA by a licensed 503A pharmacy. Compounded progesterone is not an FDA-approved drug.

How it fits your plan

Two roles, the right form, ongoing review

01

Uterine protection with estrogen

For women with a uterus on estrogen therapy, progesterone protects the uterine lining. Your clinician prescribes the two together so your plan is complete, not piecemeal.

02

Sleep and mood support

On its own, oral progesterone is often taken at night for its calming effect. Your clinician decides whether progesterone alone fits your perimenopausal symptoms.

03

Reviewed and adjusted

Where it informs the decision, your clinician reviews progesterone and related labs and adjusts the form or dose over time as your symptoms evolve.

Sourcing and safety

Bioidentical, US-compounded, and prescribed by a clinician of record.

From who writes the prescription to where your progesterone is compounded, the chain behind your medication is transparent by design.

A clinician of record

A US-licensed clinician reviews your intake, discusses the trade-offs, and is your prescriber of record. Your progesterone is never sold off a shelf.

Compounded in the USA

Your bioidentical progesterone is compounded in the USA by a licensed 503A pharmacy under your prescription. No hidden overseas supply chain.

Labs where indicated

Where it informs the decision, your clinician reviews progesterone and related hormone panels so your plan reflects what your body is missing.

An American woman in her early fifties sleeping peacefully on her side, serene and restful.

Who it's for

For women who want balance, better sleep, and a complete hormone plan.

Progesterone is considered for women taking estrogen who need uterine protection, and for women in perimenopause seeking sleep and mood support. Eligibility is a clinical decision made by your prescriber.

  • You are taking or considering estrogen and need uterine protection as part of a complete plan
  • Sleep has become lighter or more broken as you move through perimenopause
  • Mood or a sense of being on edge has shifted in a way that tracks with your cycle changes
  • You want bioidentical progesterone prescribed and monitored, not sourced off a shelf

Your clinician reviews your history for contraindications and prescribes only when the evidence supports it. Not everyone qualifies, and if progesterone is not appropriate you are never charged for a medication you were not prescribed.

A PepScribe-branded compounded bioidentical progesterone capsule bottle on a sunlit bathroom counter beside a rolled towel and a glass of water.

What you receive

One plan. Everything included.

A flat monthly price covers your compounded medication, the clinical care, and shipping. Your clinician sets the exact form and dose during your review and adjusts it over time.

  • Bioidentical progesterone prescribed for you, oral or topical, US-licensed
  • Compounded in the USA by a licensed 503A pharmacy
  • Prescribed with estrogen for uterine protection where indicated
  • Lab review where indicated, including hormone panels
  • Async messaging with your care team and dose adjustments over time
  • Cancel or pause anytime

Starting from

$139/mo
Take the free assessment

Free online visit. You only pay when prescribed.

  • Cancel anytime
  • No insurance needed
  • Discreet shipping
  • HSA/FSA eligible

Compounded progesterone is not an FDA-approved drug. Bioidentical hormone therapy is not appropriate for everyone. Form, dose, and any companion hormones are determined by a licensed clinician based on your history and, where indicated, your labs.

Compounded drug products are not approved or evaluated for safety, effectiveness, or quality by the FDA. Rx required.

Progesterone questions

Things people ask before they sign up.

If something is not here, reach out, we'd rather answer it plainly than have you guess.

What is bioidentical progesterone?

Progesterone is the hormone that balances estrogen. Bioidentical progesterone is structurally identical to what your body makes, compounded in the USA by a licensed 503A pharmacy under your prescription. It is prescribed by a US-licensed clinician and is not an FDA-approved drug.

Why is progesterone prescribed with estrogen?

For women with a uterus, progesterone protects the uterine lining during estrogen therapy. That is why your clinician prescribes the two together as part of a complete plan.

Can progesterone help with sleep?

Oral progesterone is often taken at night for its calming effect, and sleep changes are a recognized part of perimenopause that a clinician evaluates. Rather than promise a result, your clinician discusses what the evidence supports for your situation.

Will my labs be reviewed first?

Where it informs the decision, yes. Your clinician may review progesterone and related hormone panels so your plan reflects what your body needs.

How much does it cost?

The online visit is free. If a clinician prescribes, the program is $139/month on the 3-month plan ($417 billed every 3 months), covering the medication, clinician care, and shipping. Plans are HSA and FSA eligible.

A complete plan, not a piece of one.

Take the free assessment. A US-licensed clinician reviews your symptoms and, where indicated, your labs, then prescribes bioidentical progesterone only when it fits. The online visit is free, and you only pay if you're prescribed.