NAD+.
Your cells run on this stuff.
Nicotinamide adenine dinucleotide — a coenzyme in every cell of your body. Levels decline with age. Injectable NAD+ is designed to support the cellular energy production that keeps everything running.
What is NAD+?
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme present in every living cell. It plays a role in hundreds of metabolic processes — energy production, DNA repair, cellular signaling, and more. It's not a supplement trend. It's basic biochemistry.
Here's the problem: NAD+ levels decline significantly with age. By middle age, your levels may be substantially lower than they were in your 20s. This decline is associated with changes in energy, cognitive function, and metabolic health.
Injectable NAD+ is designed to support your body's cellular energy production more directly than oral supplements, which face absorption and bioavailability challenges in the digestive system.
Is NAD+ therapy right for you?
NAD+ therapy is designed for people who want to support their cellular health as they age — not treat a specific condition.
Your PepScribe clinician determines eligibility based on your health history and goals. NAD+ therapy pairs well with other protocols — your clinician can help build a plan that fits.
How NAD+ therapy works
Cellular energy support
NAD+ is a substrate for enzymes involved in mitochondrial function, including sirtuins and PARPs. These enzymes play roles in energy metabolism, DNA repair, and cellular stress responses. Supporting NAD+ levels may help maintain these processes as they naturally decline.
Subcutaneous injection
Subcutaneous injection, with frequency determined by your clinician based on your goals and response. The injectable route bypasses digestive breakdown, delivering NAD+ more directly than oral precursors like NMN or NR.
What to expect early on
Some patients report improved mental clarity and energy within the first few sessions. Others notice more gradual changes over weeks. Response varies — NAD+ is supporting background cellular processes, so the experience is individual.
What to expect
NAD+ supports processes happening at the cellular level. Some changes are noticeable, others are working behind the scenes.
The fog lifts
Many patients report a noticeable shift in mental clarity and sustained energy — the kind where you get to 3 PM and realize you didn't reach for a second coffee. Focus during deep work sessions may feel sharper. Sleep quality often improves as well.
Deeper cellular support
As NAD+ levels build with consistent therapy, patients may notice faster exercise recovery and improved stamina. The cumulative effect of supported mitochondrial function and DNA repair processes becomes more apparent in how you feel day to day.
Sustained vitality
Ongoing NAD+ support is designed to help maintain cellular energy production over the long term. Many patients describe this phase as a new baseline — not a peak, just a better version of normal. Your clinician refines the protocol to fit your lifestyle.
Individual results may vary. Timelines are based on commonly reported patient experiences and are not guaranteed outcomes.
Side effects — what to know
NAD+ therapy is generally well-tolerated. Most side effects are mild and related to the injection process itself.
Common (generally mild)
- •Injection site discomfort — temporary stinging or warmth at the injection area
- •Flushing — temporary warmth or redness, typically brief
- •Mild nausea — occasionally reported, usually transient
Less common
- •Lightheadedness during or shortly after injection
- •Muscle cramping (typically resolves with hydration)
Talk to your clinician if you experience any side effects that concern you. Adjusting injection speed, frequency, or dosage often helps manage any discomfort.
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Deep dives on NAD+
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Start NAD+ therapy assessmentCompounded medications are prepared by licensed pharmacies and are not FDA-approved. All prescriptions require approval by a licensed healthcare provider. Individual results may vary.